![]() ![]() Hanry Yu, in Encyclopedia of Biomedical Engineering, 2019 Cell differentiationĬell differentiation is known as a process in which cells become specialized. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a central role in OPC survival, as demonstrated by effects of both muscarinic and cannabinoid receptor agonists, which promote cell survival through direct activation of this pathway. OL programmed cell death is one of the crucial mechanisms that regulate the final OL number in the mature brain. ![]() Receptor activation with the agonist quinpirole led to reduced numbers of O1 + cells, along with an increase in the number of precursors, indicating that dopamine binding delays or inhibits OPC differentiation. Adenosine is a potent stimulator of OPC differentiation and myelination in DRG–OPC cultures, and ATP and ADP also promote OPC differentiation.ĭopamine D3 receptor expression was detected in OPC cultures and in the corpus callosum at the peak of myelination, but was not found in mature oligodendrocytes. Glutamate prevents OPC lineage progression to the O4 + and O1 + stage by maintaining OPCs in cell cycle arrest, whereas isoproterenol exerts opposite effects and promotes cell differentiation, as determined by a large increase in the percentage of O4 + preoligodendrocytes and O1 + oligodendrocytes. The possibility of monitoring OPC lineage progression has provided unique opportunities to investigate the effects of neurotransmitters on oligodendrocyte development and myelination. ![]() OPC differentiation can be monitored by using specific antibodies that bind to developmentally regulated antigens. Chew, in Encyclopedia of Neuroscience, 2009 Cell differentiation and survival ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |